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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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0:18 The willpower episode and the through-line 2:10 Thermodynamics: what sets both sides 2:41 Your metabolism is three things 4:05 Claim 1: my metabolism crashed 4:24 No cliff at 40: the doubly labeled water study 5:33 Real metabolic adaptation after weight loss 6:56 Why your food diary lies 7:49 Claim 2: it's my hormones 8:07 Thyroid: mostly water 9:36 Cortisol: explains about 1 percent 11:12 PCOS is now PMOS 13:06 Menopause 14:18 Claim 3: a calorie isn't a calorie 16:48 Absorption: nuts, cooking, eggs 19:44 Why calorie counting fails 21:12 Claim 4: it's not Calories, it's insulin 22:02 Testing the carbohydrate-insulin model 25:52 The GLP-1 drugs that should end it 28:34 The whole list, claim by claim 29:53 What to actually do 30:42 Next week: are GLP-1s cheating