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Additionally, 35% of subjects in the Tesamorelin group achieved a hepatic fat fraction below 5%, compared to only 4% in the control group

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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

Results depend heavily on baseline body composition, dietary adherence, exercise programming, sleep quality, stress management, genetic factors, and protocol compliance