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Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models

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Moreover, the visual assessment results and subjective evaluations reports revealed a statistically significant increase in the whitening efficacy of niacinamide after 4 and 8 weeks of therapy compared to the baseline (Lee et al., 2016b)