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In many cases, biological activity has been evaluated mainly through in vitro metabolic assays and a limited set of cellular models, which complicates the establishment of firm conclusions regarding their mechanisms of action and actual selectivity

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

These herbs have been shown to modulate the hypothalamic-pituitary-adrenal (HPA) axis and balance stress hormones like cortisol

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