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While physiologically relevant, traditional rodent studies are often low-throughput and resource-intensive (Cosgrove et al., 2009), whereas simplified in vitro systems cannot replicate the organs complex cellular interplay and spatial metabolism (Scheidecker et al., 2020)

Nanoparticle formulations of the Parkinsons drug, selegiline, resulted in 12-20 fold increases in brain concentrations in laboratory animals compared to delivering the drug orally

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The patient remained clinically well and did not show evidence of long-term consequences of the accidental overdose