Brand-Name Costs (Without Insurance): Monthly List Prices: Wegovy (semaglutide): $1,349 Ozempic (semaglutide): $969 Zepbound (tirzepatide): $1,069 Mounjaro (tirzepatide): $1,069 Saxenda (liraglutide): $1,400 Annual Costs: Semaglutide: $11,628-$16,188/year Tirzepatide: $12,828/year For 18-month treatment: $17,442-$24,282 These prices are unsustainable for most cash-pay patients
GLP-1s come in both injectable and oral forms
Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist, not a GLP-1 receptor agonist
Gallbladder-related risks are heightened during rapid weight loss, as demonstrated in trials of GLP-1 therapies and in dietary interventions such as very-low-calorie diets [33,36]