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They don't directly counteract each other's primary function

Secondary surveillance likely accounts for a large proportion of immediate or semi-delayed drug reactions, where drug derived epitope that is present in the skin is recognised by skin homing memory T-cells generated from a previous encounter with (a) the specific drug or metabolite, (b) a structurally similar drug or (c) from a pathogen derived epitope which has a similar sequence

The tirzepatide eye disease risk they warned about does not hold up the data point to less retinopathy, not more

Smith-Magenis syndrome (a congenital disorder due to a haplo-insufficiency of the retinoic acid-induced 1 gene, involved in the regulation of the expression of circadian genes) patients present with an inverted rhythmic melatonin secretion and sleep difficulties that can be managed with melatonin administration in the evening and -adrenergic blockers during the day to reduce melatonin secretion (82)