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This indicates that while CD may increase the risk of T1D, other factors that attenuate the structural integrity of the gut barrier are involved and that this is an immune disorder with multiple aetiological factors

References Health Canada

doi:10.1016/j.bcp.2017.11.007

Discussion Across rodent and cell models, NNMT inhibition acts as a metabolic re-allocator, simultaneously relieving a methyl sink and diverting nicotinamide back to NAD salvage