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The ongoing dedicated ophthalmic trial named as FOCUS study, which aims to evaluate semaglutides long-term effects on diabetic retinopathy, is now ongoing and could contribute to a comprehensive understanding of the true risk-benefit profile of these agents in patients with or at risk for diabetic retinopathy (NCT03811561) [104]

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A comprehensive biomarker assessmentincluding fasting IGF-1, cortisol, prolactin, and metabolic markerscan help providers identify whether either secretagogue aligns with individual physiology before initiating therapy

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