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Yang et al., 2016), primary murine bone marrow stromal cells (10 9 10 6 M) (Motyl et al., 2017), and the murine RAW264.7 macrophage cell line (10 4 M10 5 M) (Wang, Wang et al., 2021, 2021)

Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6

Additionally, L-ET possesses superior cellular uptake and distribution, allowing it to permeate cell membranes and accumulate within tissues, where it can exert its protective effects

In fact, acetaminophen-related liver damage is currently the most common cause of liver transplant in the US, with more than 56,000 emergency room visits per year from acetaminophen-related liver problems