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The intestinal microbiota generates n -butyrate as the predominant form of butyrate, which is metabolized into butyryl-CoA and directly regulates cellular butyrylation

Biological activity of AC3174, a peptide analog of exendin-4

Moreover, the non-viral lipid nanodelivery system that encapsulates siRNA can also target NK cells in vivo and silence the inhibitory checkpoint signaling molecules SHP-1, Cbl-b, and c-Cbl of NK cells, thereby enhancing the killing activity of NK cells against cancer cells and eliminating tumor (83)