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reported the therapeutic potential of another natural quinazoline derivative that promoted oxidative stress and increased ROS production [113]

As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run

We recently reviewed elsewhere the vast array of therapeutic opportunities that the targeting of each one of these receptors offers, not only as a hope for the future, but as a current success, as several MC drugs have already been approved and many others are in clinical phase of development (135)