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Those experiencing severe gastrointestinal side effects (persistent vomiting or diarrhoea lasting more than 24 hours) should contact their healthcare provider or NHS 111, as this increases dehydration risk and may necessitate temporary dose adjustment or additional supportive measures

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Site-directed mutagenesis Point mutations were introduced by PCR with Pfu polymerase (Promega) using the double stop-codon construct of pQE30/ SCGRX7 (ref