Gillian Goddard, MD, a board-certified endocrinologist with Park Avenue Endocrinology and Nutrition, spoke with MNT about the study findings

What to expect during the switch: 7-day gap: Stop Mounjaro on your normal injection day, then wait 7 days before starting Wegovy Starting fresh: Begin with the lowest Wegovy dose (0.25mg) regardless of your previous Mounjaro dose Gradual increase: Your dose will be increased every 4 weeks as tolerated Side effects may return: Mild nausea, stomach upset, or changes in appetite are normal initially Timeline: Week 1: Final Mounjaro dose Week 2: No medication (washout period) Week 3: Start Wegovy 0.25mg Weeks 3-6: Continue 0.25mg weekly Weeks 7-10: Increase to 0.5mg if tolerated Continue: Following the standard Wegovy dose schedule Wegovy Dose Escalation Schedule Following the 7-day washout period, you'll start Wegovy at the lowest dose and gradually increase according to the established titration schedule: Weeks 1-4 (of Wegovy treatment): 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Weeks 13-16: 1.7 mg weekly Week 17 onwards: 2.4 mg weekly (maintenance dose) This methodical approach allows your body to adapt progressively, minimising potential side effects and maximising treatment tolerability

Mild nausea, headaches, fatigue, constipation, and diarrhea are common at higher doses and can go away over time.) Stay at the same dose and message your clinician If you start experiencing unmanageable side effects Unmanageable means theyre severe, prolonged, or significantly affect your ability to function
Where AOD 9604 targets fat cells directly, tirzepatide works through the incretin system, a network of hormones that regulate appetite, digestion, and insulin secretion from the gut level upward