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Approximately 0.1-0.2% of the body's total B12 stores are lost daily through urinary and faecal excretion , representing a relatively slow depletion rate compared to other water-soluble vitamins

When used as medication, GLP-1 receptor agonists stimulate the body's insulin production during high blood sugar periods, suppress the secretion of glucagon (a hormone that raises blood sugar), and slow the emptying of the stomach

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Reviews of the scientific literature describe GHK-Cu as influencing collagen, elastin, glycosaminoglycan synthesis, metalloproteinases, and several repair-related pathways