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Another paper by the same group used 2DE and Doppler imaging demonstrated enlarged ascending aortic systolic and diastolic diameters resulting in aortic stiffness in women with lipedema compared to controls (44)

RN: Writing original draft, Methodology

Through mechanisms involving chromatin decondensation, NOR activation, and structural remodeling of heterochromatin, Livagen appears to reactivate silenced genes and counteract age-related chromatin repression, suggesting potential epigenetic rejuvenating effects at the cellular level [1]

HIF1A and HIF2A knockdown in hypoxic HK2 cells In a previous study, 10 immortalized human proximal tubular epithelial (HK2) cells with and without stable HIF1A and/or HIF2A (EPAS1) suppression were subjected to normoxic (20% O 2 ) or hypoxic (1% O 2 ) conditions for 24 h