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Moreover, the inhibition of FAK activity in macrophages drastically reduced the 25HC-induced production of both TNF and IL-6 (Fig

[DOI] [PubMed] [Google Scholar] [34].Lee WS, Wells RG, Sabbag RV, Mohandas TK, Hediger MA

Maximum effects develop over 36 months, with continued improvement as long as you remain on medication and maintain healthy eating and activity habits

This dual mechanism, weight-mediated and insulin-mediated aromatase reduction, may explain why some endometriosis patients see improvements that seem disproportionate to their weight loss alone