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Although this is a necessary first step in biomedical development, it is also a sign that R&D for these conditions operates in a somewhat rigged race, starting off with and slowed down by a lack of funding and available medical knowledge from the outset

Notably, amyloid deposits in ATTR patients correlate with markers of lipid peroxidation, such as 4hydroxytrans2nonenal (HNE) adducts [35] and oxidative DNA damage indicated by 8hydroxy2deoxyguanosine (8OhdG) [34]