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211215 Recently, GLP-1 action has additionally been expanded to potential regulation of autophagy in islet beta-cells: Exendin-4 induced autophagy in INS-1E cells and isolated human islets during chronic exposure to excess nutrients, by promotion of autophagosomal-lysosomal fusion

If more Medicare beneficiaries with obesity or overweight gain access to GLP-1s based on other approved uses for these medications, that could reduce the cost of proposed legislation to lift the statutory prohibition on Medicare coverage of anti-obesity drugs