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Effects and action mechanisms of lotus leaf ( Nelumbo nucifera ) ethanol extract on gut microbes and obesity in high-fat diet-fed rats

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On the one hand, iron can affect the secretion and sensitivity of insulin and inhibit liver glycogen production, and insulin secretion decreases with increasing liver iron storage, leading to systemic hyperinsulinemia

Furthermore, studies reveal that KYN pathway metabolites, particularly quinolinic acid (QA), are significantly elevated in CKD patients due to altered tryptophan metabolism by gut microbiota