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One study proposed that SCFAs exert their effects on leukocytes and endothelial cells via two known mechanisms, i.e., activating GPR41 and GPR43 and inhibiting the histone deacetylase (HDAC) activity (Vinolo et al., 2011)

Vitamin D deficiency was the most common nutritional problem, affecting 13.6% of participants after 12 months of treatment in the largest study (some 461,000 participants, 56% of them female)

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