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In neoplastic cells, activation of NF-B provides the ability to survive by upregulating anti-apoptotic genes, including several members of the BCL-2 family [192], and increases resistance to chemotherapy by controlling the expression of multidrug resistance gene 1 (mdr1) [193]

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Imaging Biomarkers Several imaging techniques such as magnetic resonance imaging (MRI), transcranial sonography (TCS), single-photon emission computed tomography (SPECT), and positron emission tomography (PET) have been used to identify structural changes in the substantia nigra