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Zepbound and Mounjaro contain the same active ingredient and share the same dosing structure (the KwikPen device with weekly doses ranging from a 2.5 mg starting dose up to a 15 mg maximum dose)

The free retatrutide titration calculator turns your starting dose, target dose, and step interval into a week-by-week schedule with calendar step-up dates

Tirzepatide and oral contraceptives in obesity: switch to a non-oral contraceptive or barrier method for 4 weeks after initiation or dose escalation

The company reports that "participants on 12 mg retatrutide lost an average of 70.3 lbs (28.3%) over 80 weeks with 45.3% of participants achieving 30% weight loss, a level long associated with bariatric surgery." Retatrutide is the latest compound to emerge from the revolution in hormonal treatment begun with the introduction of semaglutides like Ozempic in 2018 to treat Type 2 diabetes