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Rubino DM, Greenway FL, Khalid U et al (2022) Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes

Weight itself can affect the timeline, as semaglutide distributes throughout body tissues, meaning larger bodies may retain detectable levels slightly longer

Finally, in vitro work has looked at cellular signaling downstream of 3-AR engagement, providing mechanistic support for the lipolysis-without-hyperglycemia profile that investigators consistently observe

There is a mild positive fat-mobilization effect and appetite suppressor effect as well