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Corroborating a functional role of GIPR, GLP-1GIPLani decreased body weight and food intake with increased efficacy compared with GLP-1Lani, but with equal efficacy to co-therapy of GLP-1Lani and a long-acting GIPR agonist (acyl-GIP) (Fig

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Hence, the effects of GLP-1 RA on the central nervous system may contribute to the induction of weight loss but not necessarily to its maintenance

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Common side effects include nausea, vomiting, diarrhea, or constipation, typically mild and temporary as your body adjusts

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