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A meta-analysis of 33 randomized controlled trials (RCTs) further confirmed the renoprotective effects of statins, showing reductions in urinary albumin excretion [weighted mean difference (WMD): 2.04 mg/24 h], proteinuria (WMD: 0.58 g/24 h), and modest improvements in creatinine clearance (WMD: +0.86 ml/min) (149)

The study was not designed to compare tirzepatide against CPAP for the treatment of OSA, but did compare the effects of tirzepatide with placebo in both CPAP users and non-CPAP users with OSA and obesity

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