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297,298,299 However, ertugliflozin in the VERTIS trial did not show superiority to the placebo in T2D patients with established ASCVD

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The higher frequency of gastrointestinal side effects also observed with efinopegutide in Phase 2 trials may also be explained by a relatively high receptor potency of at GCGR and GLP-1R, within 3-fold of the native ligands (81)