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265,266 PERK-eIF2-ATF4 signaling in angiogenesis, EMT, and metastatic progression Persistent activation of the cytoprotective arm of the UPR can actively drive tumorigenesis and malignant progression

This is why lyophilized (freeze-dried) powder is inherently more stable than a pre-mixed solution: removing water removes the hydrolysis substrate

doi: 10.1016/S0140-6736(18)30485-9 71 ZhavoronkovA