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Clinical trials have demonstrated that nausea, diarrhea, vomiting, constipation, and abdominal discomfort occur frequently, particularly during dose initiation and escalation

The NHS website (nhs.uk) provides patient-facing information on weight management services and referral pathways

To minimise discomfort, eat smaller, more frequent meals, avoid high-fat or spicy foods, and stay well hydrated

In 2025, the company reported a -1.73% YoY (Jan-Dec25) decline in revenue, reflecting portfolio dynamics: Entyvio ($6.14B) continues to anchor growth in inflammatory bowel disease, Takhzyro ($1.44B) shows steady momentum in rare diseases, while Gattex/Revestive ($913.56M) remains a solid contributor in gastrointestinal disorders partially offset by generic pressure and loss of exclusivity in some legacy products