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A landmark clinical trial of semaglutide, published in 2021, found that participants experienced an average of 15% weight loss over the course of 68 weeks while those on placebo lost 2%

While taking this medication, youll release fewer hunger hormones like ghrelin, feel fuller after meals, and experience fewer reward signals from eating

Data Charting Relevant information from each included study was extracted using a data charting form that captured the following fields: author(s), year of publication, country of origin, whether the combination was an add-on or simultaneously used, study population characteristics relevant to the outcomes, and sample size, study design, intervention or exposition type and details of these, comparator, outcomes and their specifics, adverse effects reports, and key findings related to the scoping review questions

Common overlapping side effects include gastrointestinal symptoms (nausea, vomiting, abdominal pain), increased heart rate and blood pressure, and excessive appetite suppression