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PepT1 is a low-affinity ( of 200 M to 15 mM), high-capacity transporter and is known to play a pivotal role in the absorption and distribution of peptidomimetics that include -lactam antibiotics such as cephalosporins and penicillins, angiotensin converting enzyme inhibitor such as zofenopril, fosinopril, benazepril, quinapril, trandolapril, spirapril, cilazapril, ramipril, moexipril, quinaprilat, and perindopril., selected rennin inhibitors, antitumor agents such as bestatin, and dopamine receptor antagonists such as sulpiride (Terada et al

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UPR is associated with three ER transmembrane receptors: protein kinase R-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6) and inositol-requiring kinase 1 (lRE1) in mammalian cells (Szegezdi et al., 2006)

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