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Some of the most common include rheumatoid arthritis (attacking joint tissues), Hashimotos thyroiditis (affecting thyroid function), multiple sclerosis (targeting nerve myelin), psoriasis (affecting skin cells), inflammatory bowel diseases like Crohns and ulcerative colitis (involving digestive tract tissues), lupus (potentially affecting multiple organs), and type 1 diabetes (targeting insulin-producing pancreatic cells)

The small resting heart rate increase from the glucagon arm is real but minor for healthy hearts, comparable to a cup of coffee

79 In addition to their anti-diabetic effects, SGLT-2is play a role in cardio-nephroprotection due to RAAS activation from their diuretic and sympathoinhibition effects

The choice is not made once and left unchanged