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"These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy." Authors of a related commentary agreed that the findings deserve closer attention from eye specialists and researchers

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This inhibition was evidenced by Oil Red O and AdipoRed staining, and by the downregulation of key adipogenic markers, including peroxisome proliferator-activated receptor gamma ( PPAR ), lipoprotein lipase ( LPL ), fatty acid-binding protein 4 ( FABP4 ), and CCAAT/enhancer-binding protein alpha ( C/EBP ) [12, 13, 22, 23]