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Proc Natl Acad Sci U S A (1990) 87(18):72604.10.1073/pnas.87.18.7260 Summary Keywords glucagon-like peptide-1, osteogenesis, bone resorption, osteoporosis, diabetes mellitus Citation Zhao C, Liang J, Yang Y, Yu M and Qu X (2017) The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms

In the 6-OHDA rat model of PD, semaglutide normalized IRS-1 phosphorylation [130], and levels of pIRS-1 were increased by the GLP-1 receptor agonist exendin-4 and a dual GLP-1/GIP agonist, DA-CH5 [45, 131]

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However, peptide therapy for rheumatoid arthritis is still considered an emerging area of research