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losing it makes maintaining weight loss harder Higher risk of weight regain: A lower metabolic rate makes stopping or reducing medication much riskier Reduced functional strength: Weakness, limited mobility, and increased fall risk are all linked to muscle loss Impaired blood sugar regulation: Muscle plays a direct role in how the body processes glucose after meals How to Preserve Muscle Mass on GLP-1 Medications Research shows that muscle loss during GLP-1 therapy is not inevitable

Why This Matters in MCAS Many MCAS patients present with: Abdominal pain with hypersensitivity quality Post-prandial flares IBS-like patterns Burning GI discomfort without structural pathology Persistent symptoms despite antihistamines and mast cell stabilizers In these scenarios, symptoms may reflect mast cellnerve cross-talk rather than uncontrolled mediator release alone

& Mazmanian, S

Fuselier, T., Mota de Sa, P., Qadir, M