Talk with a licensed healthcare professional before beginning any prescription weight-management protocol, particularly if you have an existing medical condition, take other medications or supplements, are pregnant or nursing, or have a history of pancreatitis, gallbladder disease, an endocrine disorder, an eating disorder, or another relevant health concern
26 Experiments in pancreatic islets reveal that -arrestin limits the insulin response to GLP-1, but not GIP or tirzepatide, suggesting that the biased agonism and imbalance of tirzepatide toward the GIP receptor and its unique GLP-1 receptor signaling properties might be at the basis of its potent action
doi: 10.1172/jci.insight.159863, 82 KonanurV
It decreases glucagon secretion, delays stomach emptying, and increases the release of insulin, all of which help control blood sugar levels and promote weight loss