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The number of H-bonds formed between fusion proteins and the receptors at each step of the simulation was counted to ensure that the binding interaction was stable throughout the MD simulation

Pathway 4: Immune Modulation (KPV) Function: Inflammatory balance and resolution KPV prevents excessive inflammation that would impair healing while maintaining adequate immune response for pathogen clearance and tissue remodeling

Compared with conventional therapies, the development of therapies that simultaneously target multiple CSC phenotypes, metabolic adaptations, and TME-driven plasticity may provide a more effective strategy to prevent tumor relapse and improve treatment outcomes

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