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Mitochondrial-Derived Peptide Origins MOTS-c belongs to a small but growing class of peptides discovered to be encoded within mitochondrial DNA rather than nuclear DNA a finding that reshaped scientific understanding of what mitochondria are capable of producing

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Nat Rev Cancer 16:447462 Eriksson SE, Ceder S, Bykov VJN, Wiman KG (2019) p53 as a hub in cellular redox regulation and therapeutic target in cancer