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In a 2026 JAMA secret-shopper study, a slender Yale medical student posed as a 237-pound patient and attempted to obtain semaglutide or tirzepatide from 49 direct-to-consumer websites
Safety Concerns and Reported Complications There have been growing reports of adverse reactions associated with compounded semaglutide, including unexpected gastrointestinal side effects, excessive nausea, severe dehydration, and symptoms not typically seen with FDA-approved GLP-1 medications
Table 3 Comparable to observations during treatment with GLP-1RA, symptom-free elevations of pancreatic enzyme concentrations for amylase and lipase were seen in the above-mentioned SURPASS studies (61)
But within hours of her first dose, she said, she found herself on the phone with poison control
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