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Common Side Effects Participants in clinical studies reported: Nausea Vomiting Diarrhea Reduced appetite These symptoms typically occur during the dose escalation phase and often decrease over time

Signs of gallbladder problems, including right upper abdominal pain, jaundice, or clay-colored stools, warrant urgent assessment, as these medications can increase gallstone risk, particularly during rapid weight loss

only 43% of participants met the lower end of this g/kg/day recommendation

That will change when results of the phase 3 randomized SELECT trial (NCT03574597) are released, perhaps as soon as 2023 or early 2024