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Measures of effect size were expressed as odds ratios (ORs) with 95% confidence intervals [95% CI] and the I2 statistic was calculated to quantify trial heterogeneity or inconsistency

Direct comparison requires matching vial sizes, purity claims, and testing documentation depth

Weight typically returns gradually over 6-12 months after discontinuation because the underlying biological drivers of weight gain (hunger signals, insulin resistance, metabolic rate) return to baseline

Comparing Semaglutide, Tirzepatide, and Combination Therapies at PlexusDx PlexusDx offers compounded semaglutide at $189/mo month-to-month, or from $149/mo on the 6-month plan, but patients with type 2 diabetes or superior weight-loss goals may benefit from tirzepatidea dual GIP/GLP-1 receptor agonistwhich is $289/mo month-to-month, or from $249/mo on the 6-month plan