Interestingly, GI adverse events and GLP-1 RA discontinuations were more common in participants not treated with metformin, which may represent increased susceptibility of this group to gut-related adverse events, resulting in intolerance to metformin previously as well as to GLP-1 RAs in the trials
One commentator recently made the following observation, if just 10% of Medicare beneficiaries (~65m people) were treated with Wegovy (the Novo Nordisk Semaglutide drug used in the Select study), to treat all obese American adults with these drugs at current prices, it would cost US$1.3trn
Jackson LeMay, who lives in Lilburn, Georgia, said his experience with food noise a constant, insatiable itch lasted over a decade and dates to high school
If this trajectory holds in phase 3, amycretin could achieve greater long-term weight loss