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Perkovic V, de Zeeuw D, Mahaffey KW, Fulcher G, Erondu N, Shaw W, Barrett TD, Weidner-Wells M, Deng H, Matthews DR, Neal B

Key Benefits of Sermorelin Enhances natural GH production and IGF-1 levels Supports muscle development, fat metabolism, and recovery A safer long-term alternative to exogenous GH therapy Lower risk of GH overstimulation and side effects Sermorelin is frequently used in longevity medicine, sports recovery, and metabolic health programs, offering a more physiological approach to hormone therapy

Data availability Because the model population is derived from de-identified registry data, the data cannot be made available owing to privacy concerns

Future therapies may be tailored based on a patients ferroptosis signaturehigh levels of lipid peroxidation products might indicate a subgroup that would derive maximum benefit from inhaled ferroptosis inhibitors added to their standard care