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However, the description of the six nutritional phases in PWS has significantly improved our understanding of the natural history of the syndrome ( Clinical manifestations related to PWS appear to involve a complex dysregulation of the hypothalamus, affecting both the adeno- and neurohypophysis ( 2 Aim and search methods Genotype-phenotype correlation is a relationship that examines how the presence of a clinical trait corresponds with a group of similar mutations

Additionally, the applicant asserted that the specific substantial clinical improvement claim addressed by Geldmaker et al

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