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Besides the commonly used liquid formulation, the development and engineering of dry powders using a spray dryer look attractive due to their higher long-term storage stability, increased mucoadhesion, and enhanced permeation across biological membranes

Ethics statement The studies involving human participants were reviewed and approved by CAMH Research Ethics Board

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The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione