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Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved Trial

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GP (that is PDB 1GP1, according to Protein Data Bank, and EC 1.11.1.9, according to the Enzyme Commission numbering) is the main term of an enzyme family with peroxidase activity

they can generate mechanical force via enzyme-driven or physical-driven mechanisms to actively penetrate dense stroma, while enhancing therapeutic efficacy by regulating microenvironmental parameters (e.g., alleviating hypoxia and remodeling immune balance) [274]