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In fact, some studies in rats supplemented with creatine report greater plasma glycine concentrations ( via fatty acid transport into the mitochondria ( In vertebrates, creatine is irreversibly and non-enzymatically dehydrated to produce creatinine at a rate of about 1.52% of the total creatine pool per day ( Sources of creatine in pet food are animal tissues and by-products

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We follow your response, look at relevant labs over time, and adjust dosing or switch protocols when the data tells us to