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When the body has difficulty breaking down histamine, it can lead to a variety of symptoms, including: Head: Headaches or migraines, dizziness, lightheadedness Skin: Flushing, skin rashes (like hives), itchy skin or eyes Respiratory: Nasal congestion, runny nose, asthma-like symptoms (wheezing, shortness of breath) Gastrointestinal: Bloating, diarrhea, nausea, digestive issues Heart: Low blood pressure, palpitations Other: Anxiety, irritability, fatigue, sleep disturbances or insomnia Salicylate Intolerance Salicylates are naturally occurring chemicals found in many fruits, vegetables, herbs, spices, processed foods, as well as certain medications and topical products

This suggests oral, cutaneous (patch) or subcutaneous (as with pen delivery) routes

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Its endogenous form has a plasma half-life of only 2-3 minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) and renal clearance