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Beyond its insulinotropic effects, GLP-1R signaling also influences lipid metabolism by modulating hepatic lipid handling and adipose tissue function

Tirzepatide also reduces liver fat, and SURMOUNT trial substudies have shown meaningful improvements in hepatic steatosis

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Furthermore, hormonal signals from the gastrointestinal tract, such as leptin and ghrelin , contribute to the bodys overall energy balance and influence the hypothalamus in modulating hunger and satiety cues