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Peregud DI, Gulyaeva NV (2024) Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction between Central and Peripheral Mechanisms

Metabolic adaptation, the body resetting its energy balance to a lower expenditure level during weight loss, means that the post-treatment metabolic rate is lower than before treatment began

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However, if you consistently skip doses or delay treatment for multiple weeks, your drug levels fall below therapeutic thresholds and appetite suppression diminishes